Biography
Dr. Marion Peters is a Professor of Medicine and holds the John V. Carbone, M.D., Endowed Chair in Medicine. She is also Chief of Hepatology Research. Dr. Peters is especially interested in the immunology of chronic liver diseases, particularly viral and autoimmune hepatitis. Her research activities include studies of transgenic mouse models of liver specific T cell responses, HIV and HCV coinfection, and alcohol and HCV infection.
Dr. Peters graduated from Melbourne University Medical School, Australia in 1972. She trained in gastroenterology, hepatology and immunology at St. Vincent's Hospital, Melbourne, University of Southern California and National Institutes of Health. She was Chief of Hepatology and medical director of Liver Transplantation at Washington University School of Medicine from 1985 to 1998.
Education
Melbourne University Medical School, Melbourne, Australia, M.B.B.S., 1972, Medicine
St. Vincent's Hospital Medical School, Melbourne, Australia, Medicine
Melbourne University, M.D., 1991, Medicine/Immunology
1973-76 Resident and Registrar in Internal Medicine, St.Vincent's Hospital, Melbourne, Australia
1976-77 Clinical Research Registrar to Dr. I. R. Mackay, Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Board Certifications
American Board of Internal Medicine, Internal Medicine
Clinical Expertise
Alcoholic Liver Disease
Autoimmune Hepatitis
Benign Liver Tumors
Cirrhosis
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Live Donor Liver Transplantation
Liver Transplantation
Nonalcoholic Fatty Liver Disease
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis
Clinical Trials
- Nitazoxanide Plus Ribavirin and Peginterferon for Therapy of Treatment Naive HCV Genotype 1 and HIV Coinfected Subjects (NCT00991289)Related Conditions: HIV/AIDS, Hepatitis C, Hepatitis A, Hepatitis| Start Date: | End Date:
- A Comparison of Adefovir and Tenofovir for the Treatment of Lamivudine-Resistant Hepatitis B Virus in People With HIV (NCT00033163)Related Conditions: HIV/AIDS, Hepatitis B, Hepatitis A, Hepatitis| Start Date: | End Date:
Program Affiliations
UCSF Liver Center
Member, UCSF Immunology Graduate Program
UCSF Helen Diller Family Comprehensive Cancer Center
Grants and Funding
- UCSF Liver Center | NIH | 1985-07-01 - 2023-05-31 | Role: Co-Investigator
- NRSA Hepatology Training Grant | NIH | 2001-12-01 - 2022-06-30 | Role: Co-Principal Investigator
- HIV status and reproductive aging affect liver fibrosis in HIV/HCV infected women | NIH | 2010-03-15 - 2013-02-28 | Role: Principal Investigator
- General Clinical Research Center | NIH | 1974-12-01 - 2009-03-31 | Role: Co-Investigator
- GENERAL CLINICAL RESEARCH CENTER | NIH | 1974-10-01 - 2009-03-31 | Role: Co-Investigator
- HCV &ALCHOOL-- EPIDEMIOLOGY &HOST-VIRUS CORRELATES | NIH | 2000-09-30 - 2006-07-31 | Role: Principal Investigator
- INTESTINAL IMMUNE RESPONSE INFLAMMATORY BOWL DISEASE | NIH | 1995-09-30 - 2001-08-31 | Role: Principal Investigator
- INTESTINAL IMMUNE RESPONSE IN INFLAMMATORY BOWEL DISEASE | NIH | 1991-06-25 - 1995-10-31 | Role: Principal Investigator
Research Narrative
My major interest is in viral hepatitis and the role of the host immune response. My work focuses on interactions among alcohol use, cannabis use and HIV co-infection on fibrotic outcomes of HCV infection. We are currently evaluating the predictors of progression of liver disease in HIV and HCV coinfected women within the Women's Interagency HIV Study (WIHS): the role of alcohol, cannabis, HIV status and control as well as reproductive aging on the severity and rate of progression of liver disease.
We are also studying adherence to antiretroviral therapy in HIV/HCV co-infected women and on HCV-specific and innate immune responses in persons co-infected with HCV and HIV. I work within the AIDS Clinical Trial Group to develop clinical trials in viral hepatitis and HIV and within the Women's Interagency HIV Study (WIHS) to examine predictors of liver-related morbidity and mortality in a cohort of women with HIV/HCV infection.
Research Interests
Liver Injury and Repair
Viral hepatitis and the role of the host immune response.
Publications
- Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate.| | PubMed
- Hepatitis B virus infection.| | PubMed
- Similar Low Rates of HCV Recurrence in HCV/HIV- and HCV-Infected Participants who Achieved SVR After DAA Treatment: Interim Results From the ACTG A5320 Viral Hepatitis C Infection Long-term Cohort Study (V-HICS).| | PubMed
- An Assessment of the Clinical Accuracy of Ultrasound in Diagnosing Cirrhosis in the Absence of Portal Hypertension.| | PubMed
- Contribution of Liver Fibrosis and Microbial Translocation to Immune Activation in Persons Infected With HIV and/or Hepatitis C Virus.| | PubMed
- Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy.| | PubMed
- Macrophage Activation and the Tumor Necrosis Factor Cascade in Hepatitis C Disease Progression Among HIV-Infected Women Participating in the Women's Interagency HIV Study.| | PubMed
- Moderate Alcohol Use Is Not Associated With Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women: A Prospective Cohort Study.| | PubMed
- Human immunodeficiency virus and liver disease: A comprehensive update.| | PubMed
- Reproductive Aging and Hepatic Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women.| | PubMed