Biography
Dr. Marion Peters is a Professor of Medicine and holds the John V. Carbone, M.D., Endowed Chair in Medicine. She is also Chief of Hepatology Research. Dr. Peters is especially interested in the immunology of chronic liver diseases, particularly viral and autoimmune hepatitis. Her research activities include studies of transgenic mouse models of liver specific T cell responses, HIV and HCV coinfection, and alcohol and HCV infection.
Dr. Peters graduated from Melbourne University Medical School, Australia in 1972. She trained in gastroenterology, hepatology and immunology at St. Vincent's Hospital, Melbourne, University of Southern California and National Institutes of Health. She was Chief of Hepatology and medical director of Liver Transplantation at Washington University School of Medicine from 1985 to 1998.
Education
Melbourne University Medical School, Melbourne, Australia, M.B.B.S., 1972, Medicine
St. Vincent's Hospital Medical School, Melbourne, Australia, Medicine
Melbourne University, M.D., 1991, Medicine/Immunology
1973-76 Resident and Registrar in Internal Medicine, St.Vincent's Hospital, Melbourne, Australia
1976-77 Clinical Research Registrar to Dr. I. R. Mackay, Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
1977-78 Gastroenterology Registrar, St. Vincent's Hospital, Melbourne, Australia
1978-80 Clinical Research Fellow in Hepatology to Dr. T. B. Reynolds, University of Southern California, Los Angeles, CA
1980-83 Visiting Fogarty Fellow to Dr. A.S. Fauci, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD
1983-85 Visiting Staff Fellow to Liver Diseases Section, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD
Board Certifications
American Board of Internal Medicine, Internal Medicine
Clinical Expertise
Alcoholic Liver Disease
Autoimmune Hepatitis
Benign Liver Tumors
Cirrhosis
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Live Donor Liver Transplantation
Liver Transplantation
Nonalcoholic Fatty Liver Disease
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis
Program Affiliations
UCSF Liver Center
Member, UCSF Immunology Graduate Program
UCSF Helen Diller Family Comprehensive Cancer Center
Grants and Funding
- UCSF Liver Center | NIH | 1985-07-01 - 2023-05-31 | Role: Co-Investigator
- NRSA Hepatology Training Grant | NIH | 2001-12-01 - 2022-06-30 | Role: Co-Principal Investigator
- HIV status and reproductive aging affect liver fibrosis in HIV/HCV infected women | NIH | 2010-03-15 - 2013-02-28 | Role: Principal Investigator
- General Clinical Research Center | NIH | 1974-12-01 - 2009-03-31 | Role: Co-Investigator
- GENERAL CLINICAL RESEARCH CENTER | NIH | 1974-10-01 - 2009-03-31 | Role: Co-Investigator
- HCV &ALCHOOL-- EPIDEMIOLOGY &HOST-VIRUS CORRELATES | NIH | 2000-09-30 - 2006-07-31 | Role: Principal Investigator
- INTESTINAL IMMUNE RESPONSE INFLAMMATORY BOWL DISEASE | NIH | 1995-09-30 - 2001-08-31 | Role: Principal Investigator
- INTESTINAL IMMUNE RESPONSE IN INFLAMMATORY BOWEL DISEASE | NIH | 1991-06-25 - 1995-10-31 | Role: Principal Investigator
Research Narrative
My major interest is in viral hepatitis and the role of the host immune response. My work focuses on interactions among alcohol use, cannabis use and HIV co-infection on fibrotic outcomes of HCV infection. We are currently evaluating the predictors of progression of liver disease in HIV and HCV coinfected women within the Women's Interagency HIV Study (WIHS): the role of alcohol, cannabis, HIV status and control as well as reproductive aging on the severity and rate of progression of liver disease.
We are also studying adherence to antiretroviral therapy in HIV/HCV co-infected women and on HCV-specific and innate immune responses in persons co-infected with HCV and HIV. I work within the AIDS Clinical Trial Group to develop clinical trials in viral hepatitis and HIV and within the Women's Interagency HIV Study (WIHS) to examine predictors of liver-related morbidity and mortality in a cohort of women with HIV/HCV infection.
Research Interests
Liver Injury and Repair
Viral hepatitis and the role of the host immune response.
Publications
- Diagnostic Utility of Pre-Genomic Hepatitis B RNA in the Evaluation of HBV/HIV Coinfection.| | PubMed
- Chronic Hepatitis B Finite Treatment: Similar and Different Concerns With New Drug Classes.| | PubMed
- Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBV.| | PubMed
- Comparison of Antiretroviral Therapies in Pregnant Women Living With Human Immunodeficiency Virus and Hepatitis B Virus: A Randomized Controlled Trial.| | PubMed
- Adverse Impact of HIV-1 on Long-term Outcomes Following HCV DAA Treatment: Final Results of ACTG A5320, the Viral Hepatitis C Infection Long-term Cohort Study (VHICS).| | PubMed
- Hepatocellular carcinoma presentation and prognosis among Nigerian adults with and without HIV.| | PubMed
- Introducing Norah Terrault, MD, MPH, Our 2023 AASLD President.| | PubMed
- Brief Report: Impact of Antiretroviral Regimen on Pregnancy and Infant Outcomes in Women With HIV/ HBV Coinfection.| | PubMed
- Hepatitis B surface antigen and hepatitis B RNA changes in HIV/hepatitis B virus co-infected participants receiving hepatitis B virus-active antiretroviral therapy.| | PubMed
- Continued Low Rates of Hepatitis C Virus (HCV) Recurrence in HCV/HIV- and HCV-Infected Participants Who Achieved Sustained Virologic Response After Direct-Acting Antiviral Treatment: Final Results From the AIDS Clinical Trials Group A5320 Viral Hepatitis| | PubMed
- Treatment Algorithm for Managing Chronic Hepatitis B Virus Infection in the United States: 2021 Update.| | PubMed
- Decreases in markers of monocyte/macrophage activation after hepatitis C eradication in HIV/hepatitis C virus coinfected women.| | PubMed
- Risk of HCC With Hepatitis B Viremia Among HIV/HBV-Coinfected Persons in North America.| | PubMed
- A Multiancestry Sex-Stratified Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.| | PubMed
- Hepatotoxicity and Liver-Related Mortality in Women of Childbearing Potential Living With Human Immunodeficiency Virus and High CD4 Cell Counts Initiating Efavirenz-Containing Regimens.| | PubMed
- Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015.| | PubMed
- Retrospective-prospective study of safety and efficacy of sofosbuvir-based direct-acting antivirals in HIV/HCV-coinfected participants with decompensated liver disease pre- or post-liver transplant.| | PubMed
- Correction: Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection.| | PubMed
- Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection.| | PubMed
- Association Between Seroclearance of Hepatitis B Surface Antigen and Long-term Clinical Outcomes of Patients With Chronic Hepatitis B Virus Infection: Systematic Review and Meta-analysis.| | PubMed
- The Pathogenesis of Liver Disease in People Living With Human Immunodeficiency Virus: The Emerging Role of the Microbiome.| | PubMed
- HCV treatment barriers among HIV/HCV co-infected patients in the US: a qualitative study to understand low uptake among marginalized populations in the DAA era.| | PubMed
- Determinants of Liver Complications Among HIV/Hepatitis B Virus-Coinfected Patients.| | PubMed
- HIV and the liver.| | PubMed
- Ledipasvir/Sofosbuvir for 8 Weeks to Treat Acute Hepatitis C Virus Infections in Men With Human Immunodeficiency Virus Infections: Sofosbuvir-Containing Regimens Without Interferon for Treatment of Acute HCV in HIV-1 Infected Individuals.| | PubMed
- Metabolic syndrome and liver steatosis occur at lower body mass index in US Asian patients with chronic hepatitis B.| | PubMed
- Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Introduction and Immunology.| | PubMed
- Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Patients with Hematological and Solid Tumor Malignancies.| | PubMed
- Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients.| | PubMed
- Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Other Populations and Newer Agents.| | PubMed
- Post-sustained Virologic Response Liver Stiffness May Underestimate Fibrosis After Direct Acting Antiviral-containing Therapy.| | PubMed
- Long-Term Use of Azathioprine in the Management of Autoimmune Hepatitis.| | PubMed
- Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.| | PubMed
- Direct-acting antiviral treatment for HIV/HCV patients in safety net settings: patient and provider preferences.| | PubMed
- Hepatitis B Virus Infection: What Is Current and New.| | PubMed
- Cost-effectiveness of Hepatitis B Virus Infection Screening and Treatment or Vaccination in 6 High-risk Populations in the United States.| | PubMed
- Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.| | PubMed
- Universal Screening of Pregnant Women for Hepatitis C: The Time Is Now.| | PubMed
- Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy.| | PubMed
- A Tough Egg to Crack.| | PubMed
- Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate.| | PubMed
- Hepatitis B virus infection.| | PubMed
- Similar Low Rates of HCV Recurrence in HCV/HIV- and HCV-Infected Participants who Achieved SVR After DAA Treatment: Interim Results From the ACTG A5320 Viral Hepatitis C Infection Long-term Cohort Study (V-HICS).| | PubMed
- An Assessment of the Clinical Accuracy of Ultrasound in Diagnosing Cirrhosis in the Absence of Portal Hypertension.| | PubMed
- Contribution of Liver Fibrosis and Microbial Translocation to Immune Activation in Persons Infected With HIV and/or Hepatitis C Virus.| | PubMed
- Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy.| | PubMed
- Macrophage Activation and the Tumor Necrosis Factor Cascade in Hepatitis C Disease Progression Among HIV-Infected Women Participating in the Women's Interagency HIV Study.| | PubMed
- Moderate Alcohol Use Is Not Associated With Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women: A Prospective Cohort Study.| | PubMed
- Human immunodeficiency virus and liver disease: A comprehensive update.| | PubMed
- Reproductive Aging and Hepatic Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women.| | PubMed
- Controlled attenuation parameter and magnetic resonance spectroscopy-measured liver steatosis are discordant in obese HIV-infected adults.| | PubMed
- The effect of HIV infection and HCV viremia on inflammatory mediators and hepatic injury-The Women's Interagency HIV Study.| | PubMed
- Management of Autoimmune Hepatitis in Pregnant Women.| | PubMed
- New Direct-Acting Antiviral Agents and Immunomodulators for Hepatitis B Virus Infection.| | PubMed
- Use of Current and New Endpoints in the Evaluation of Experimental Hepatitis B Therapeutics.| | PubMed
- Sofosbuvir Plus Ribavirin Without Interferon for Treatment of Acute Hepatitis C Virus Infection in HIV-1-Infected Individuals: SWIFT-C.| | PubMed
- Histology Rings True.| | PubMed
- Human immunodeficiency virus-infected and uninfected adults with non-genotype 3 hepatitis C virus have less hepatic steatosis than adults with neither infection.| | PubMed
- Sonography Predicts Liver Steatosis in Patients With Chronic Hepatitis B.| | PubMed
- Sex differences in the association of HIV infection with hepatic steatosis.| | PubMed
- Autoimmune hepatitis: review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria.| | PubMed
- Advancing the regulatory path on hepatitis B virus treatment and curative research: a stakeholders consultation.| | PubMed
- Screening for hepatocellular carcinoma: What is missing?| | PubMed
- Risk of End-Stage Liver Disease in HIV-Viral Hepatitis Coinfected Persons in North America From the Early to Modern Antiretroviral Therapy Eras.| | PubMed
- Hepatic fibrosis and immune phenotype vary by HCV viremia in HCV/HIV co-infected subjects: A Women's interagency HIV study.| | PubMed
- Isolated Hepatitis B Core Antibody Status Is Not Associated With Accelerated Liver Disease Progression in HIV/Hepatitis C Coinfection.| | PubMed
- Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C.| | PubMed
- Marijuana Use Is Not Associated With Progression to Advanced Liver Fibrosis in HIV/Hepatitis C Virus-coinfected Women.| | PubMed
- Use of Palliative Care Consultation for Patients with End-Stage Liver Disease: Survey of Liver Transplant Service Providers.| | PubMed
- Interferon Stimulated Gene Expression in HIV/HCV Coinfected Patients Treated with Nitazoxanide/Peginterferon-Alfa-2a and Ribavirin.| | PubMed
- Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV.| | PubMed
- Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women.| | PubMed
- Association of HIV, Hepatitis C Virus, and Liver Fibrosis Severity With the Enhanced Liver Fibrosis Score.| | PubMed
- Interferon Lambda 4 Genotype Is Not Associated with Recurrence of Oral or Genital Herpes.| | PubMed
- Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels.| | PubMed
- A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2015 Update.| | PubMed
- Mother-to-child transmission of hepatitis B virus in sub-Saharan Africa: time to act.| | PubMed
- Turnover rates of hepatic collagen and circulating collagen-associated proteins in humans with chronic liver disease.| | PubMed
- Direct and Indirect Serum Markers of Liver Fibrosis Compared with Transient Elastography among Women in the Women's Interagency HIV Study.| | PubMed
- Survey of Asian patients with hepatitis B infection: limited knowledge of transmission and screening of family members.| | PubMed
- Association of chronic hepatitis C infection with T-cell phenotypes in HIV-negative and HIV-positive women.| | PubMed
- Advances in therapy for HIV/hepatitis C virus-coinfected patients in the liver transplant setting.| | PubMed
- Characteristics and management of patients with chronic hepatitis B in an integrated care setting.| | PubMed
- Addition of nitazoxanide to PEG-IFN and ribavirin to improve HCV treatment response in HIV-1 and HCV genotype 1 coinfected persons naïve to HCV therapy: results of the ACTG A5269 trial.| | PubMed
- Liver disease in women: the influence of gender on epidemiology, natural history, and patient outcomes.| | PubMed
- Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.| | PubMed
- Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.| | PubMed
- Association of HIV infection, hepatitis C virus infection, and metabolic factors with liver stiffness measured by transient elastography.| | PubMed
- Suppression of HBV by tenofovir in HBV/HIV coinfected patients: a systematic review and meta-analysis.| | PubMed
- Microbial translocation and liver disease progression in women coinfected with HIV and hepatitis C virus.| | PubMed
- Hepatitis C viremia is associated with cytomegalovirus IgG antibody levels in HIV-infected women.| | PubMed
- Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.| | PubMed
- Racial/ethnic differences in spontaneous HCV clearance in HIV infected and uninfected women.| | PubMed
- Lower liver-related death in African-American women with human immunodeficiency virus/hepatitis C virus coinfection, compared to Caucasian and Hispanic women.| | PubMed
- Untreated HIV infection is associated with higher blood alcohol levels.| | PubMed
- Assessing mortality in women with hepatitis C virus and HIV using indirect markers of fibrosis.| | PubMed
- Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons.| | PubMed
- Effects of hepatitis C and HIV on cognition in women: data from the Women's Interagency HIV Study.| | PubMed
- Validation and modification of simplified diagnostic criteria for autoimmune hepatitis in children.| | PubMed
- Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C virus-co-infected patients.| | PubMed
- Resistance patterns and response to entecavir intensification among HIV-HBV-coinfected adults with persistent HBV viremia.| | PubMed
- The relation of HLA genotype to hepatitis C viral load and markers of liver fibrosis in HIV-infected and HIV-uninfected women.| | PubMed
- Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice.| | PubMed
- Sustained long-term antiviral maintenance therapy in HCV/HIV-coinfected patients (SLAM-C).| | PubMed
- Adipose tissue and metabolic factors associated with steatosis in HIV/HCV coinfection: histology versus magnetic resonance spectroscopy.| | PubMed
- Complement mediated hepatocytes injury in a model of autoantibody induced hepatitis.| | PubMed
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.| | PubMed
- Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia.| | PubMed
- Entering the new era of therapy for HBV and HCV infections.| | PubMed
- Recommendations for prevention, screening, and diagnosis of HBV and HCV infections.| | PubMed
- Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.| | PubMed
- End-stage liver disease in HIV disease.| | PubMed
- Long-term serologic follow-up of isolated hepatitis B core antibody in HIV-infected and HIV-uninfected women.| | PubMed
- Special populations with hepatitis B virus infection.| | PubMed
- Hepatitis C seropositivity and kidney function decline among women with HIV: data from the Women's Interagency HIV Study.| | PubMed
- New therapies for hepatitis C virus infection.| | PubMed
- Fourth HIV & Hepatitis Coinfection Workshop; June 19-21, 2008; Madrid, Spain.| | PubMed
- Risk factors for hepatitis B infection in rural Vietnam.| | PubMed
- Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay.| | PubMed
- Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis.| | PubMed
- Care of HIV patients with chronic hepatitis B: updated recommendations from the HIV-Hepatitis B Virus International Panel.| | PubMed
- The challenge of diagnosing autoimmune hepatitis: less is more.| | PubMed
- Hepatitis resulting from liver-specific expression and recognition of self-antigen.| | PubMed
- The insulin-like growth factor axis and risk of liver disease in hepatitis C virus/HIV-co-infected women.| | PubMed
- Influence of cannabis use on severity of hepatitis C disease.| | PubMed
- Diagnosis and management of hepatitis B virus and HIV coinfection.| | PubMed
- Role of alphavbeta6 integrin in acute biliary fibrosis.| | PubMed
- Awareness of hepatitis C infection among women with and at risk for HIV.| | PubMed
- Differences between Caucasian, African American, and Hispanic patients with primary biliary cirrhosis in the United States.| | PubMed
- Prevalence and long-term effects of occult hepatitis B virus infection in HIV-infected women.| | PubMed
- Chronic hepatitis B: a global health problem requiring coherent worldwide treatment strategies.| | PubMed
- HIV and liver disease forum: conference proceedings.| | PubMed
- Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel.| | PubMed
- Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjects.| | PubMed
- Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women.| | PubMed
- Viral hepatitis in HIV infection.| | PubMed
- Viral factors associated with cytokine expression during HCV/HIV co-infection.| | PubMed
- Effects of HCV treatment on cytokine expression during HCV/HIV coinfection.| | PubMed
- Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127.| | PubMed
- Novel model of antigen-specific induction of bile duct injury.| | PubMed
- De novo malignancies following liver transplantation: a case-control study with long-term follow-up.| | PubMed
- Eosinophilic hepatitis caused by lamotrigine.| | PubMed
- Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection.| | PubMed
- Chronic hepatitis B: a critical appraisal of current approaches to therapy.| | PubMed
- Clinical presentation and course of acute hepatitis C infection in HIV-infected patients.| | PubMed
- Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis.| | PubMed
- Recurrent primary biliary cirrhosis: peritransplant factors and ursodeoxycholic acid treatment post-liver transplant.| | PubMed
- Managing hepatitis B coinfection in HIV-infected patients.| | PubMed
- Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection.| | PubMed
- Viral kinetics in hepatitis C or hepatitis C/human immunodeficiency virus-infected patients.| | PubMed
- Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons.| | PubMed
- Antiviral therapy: nucleotide and nucleoside analogs.| | PubMed
- Prolonged follow-up of patients in the U.S. multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis.| | PubMed
- Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B.| | PubMed
- Hepatitis C and alcohol: fundamental and translational research directions.| | PubMed
- Detection of primary hepatic malignancy in liver transplant candidates: prospective comparison of CT, MR imaging, US, and PET.| | PubMed
- Alcohol use and hepatitis C.| | PubMed
- Animal models of autoimmune liver disease.| | PubMed