University of California San Francisco

Alexander R. Gottschalk, MD, PhD

Gottschalk
Alexander R. Gottschalk, MD, PhD

Professor of Radiation Oncology
Director, CyberKnife Radiosurgery Program
Department of Radiation Oncology

Address

1600 Divisadero, #H1014
San Francisco, CA 94115
United States

Email: [email protected]

Biography

I am involved with the Urologic, Thoracic, Orthopedic and Gastrointestinal Oncology programs at UCSF. I spend 4 days per week providing clinical coverage for the above programs program. On average, I see 6 new patient consultations per week and 15 patients on treatment. I am responsible for patient simulations, treatment planning, supervision of external-beam radiation therapy, on-treatment visits, and follow-up visits. In addition, I am involved in the brachytherapy, intra-operative radiation therapy and stereotactic body radiotherapy programs. I attend tumor boards for GU, Thoracic, GI, orthopedic oncology programs and at the Veterans Administration Hospital. I work very closely with radiation oncology residents and medical students in all the above activities. I am the Director of the CyberKnife Radiosurgery Program at UCSF and proctor other faculty in this area. As Vice Chair of clinical services I over see clinical operations at the Mount Zion site, and over see the site directors at both the Parnassus Mission Bay and Washington Hospital.

Education

Institution Degree Dept or School End Date
University of Chicago M.D. School of Medicine 1996

Board Certifications

American Board of Radiology

Awards & Honors

Award Conferred By Date
Commitment to Patient Care Award UCSF 2012/2013
Lifetime Teaching Award UCSF 2012/2013
Educator of the Year UCSF 2009/2010

Clinical Expertise

Brain and Spinal Tumors
CyberKnife Irradiation for Lung and Skull Base
Esophageal Cancer
Intensity-modulated radiation therapy (IMRT)
Sarcoma
Stereotactic Lung Radiotherapy (SBRT)
Non-Small Cell Lung Cancer
Small-Cell Lung Cancer
External-beam Radiation
Bronchioloalveolar Carcinoma (BAC)

Program Affiliations

Thoracic Oncology Program
Department of Radiation Oncology
Helen Diller FamilyComprehensive Cancer Center
Sarcoma Program

 

Research Narrative

Dr. Gottschalk is involved in a number of clinical research projects. First, he has studied several methods of image-guided radiotherapy (IGRT), including, ultrasound, electronic portal imagining using gold seed fiducial markers and megavoltage cone-beam CT (MVCBCT). His research is one of the first to evaluate prostate bed motion in patients undergoing radiotherapy after prostatectomy. Dr. Gottschalk has investigated the use of MVCBCT for dose calculation and re-calculation as well as a novel high quality, low dose, imaging beam line. The dose re-calculation can be use for dose guided radiation therapy (DGRT).

Second, using the Radiation Oncology clinical database, Dr. Gottschalk has studied: the effectiveness of intraoperative radiation therapy (IORT) in the management of extremity sarcomas and renal cell carcinoma recurrences, permanent seed brachytherapy and high dose-rate brachytherapy (HDR) for the treatment of prostate cancer both as primary therapy and as salvage after radiation failures.

Third, he has been involved as a co-investigator in three trials: a Phase 2, Single-Center, Open-Label phase I/II study to evaluate safety and efficacy and Safety in patients who have resectable esophageal cancer and are treated with neoadjuvant cisplatin, irinotecan (CPT-11), ZD1839 (IRESSA®), and radiotherapy followed by surgical resection; a phase II study of radiation therapy, paclitaxel poliglumex and carboplatin in stage III non-small cell lung cancer; and a phase I/II open-label dose escalation study of anti-CTLA4 antibody with radiation for metastatic hormone refractory prostate cancer.

 Forth, Dr. Gottschalk is involved with several RTOG (Radiation Therapy Oncology Group) studies. These have included several prostate cancer trials that investigate: high-dose vs standard-dose readiation for intermediate-risk prostate cancer; brachytherapy vs external-beam radiation plus brachytherapy for intermediate-risk prostate cancer; and standard fractionation vs hypofractionation for low-risk prostate cancer. Finally, as Director of the CyberKnife Radiosurgery Program Dr. Gottschalk oversees several of the stereotactic body radiosugery (SBRT) trials for lung and prostate cancer. He has a particular interest in the use of CyberKnife SBRT for the treatment of prostate cancer, kidney cancer, and lung cancer.

Research Interests

  • Radiation in combination with chemotherapy and targeted agents
  • Image-guided and adaptive radiation therapy
  • Radiation sensitizers and protectors

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 10
  1. Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.
    Duan X, Zhang C, Ott S, Zhang Z, Ruse C, Dannhäuser S, Jacobi R, Ehmann N, Sachidanandan D, Nagel G, Heckmann M, Kittel RJ, Gottschalk A, Claridge-Chang A, Gao S| | PubMed
  2. In situ structure of a gap junction-stomatin complex.
    Rosenkranz N, Birtasu AN, Wieland K, Rehm L, Sharma R, Vats A, Manger S, Srivastava A, Bhattacharya A, Hummer G, Frangakis AS, Gottschalk A| | PubMed
  3. Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions.
    Ruse C, Liewald JF, Seidenthal M, Tillert L, Vierock J, Gottschalk A| | PubMed
  4. Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.
    Dunkel E, Aoki I, Bergs A, Gottschalk A| | PubMed
  5. Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles.
    Seidenthal M, Redzovic J, Liewald JF, Rentsch D, Shapiguzov S, Schuh N, Rosenkranz N, Eimer S, Gottschalk A| | PubMed
  6. A Quality Control Procedure for Single Fiducial Tracking of Lung Lesions.
    Descovich M, Lau E, Hasse K, Gottschalk A| | PubMed
  7. Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.
    Shao J, Liewald JF, Steuer Costa W, Ruse C, Gruber J, Djamshedzad MS, Gebhardt W, Gottschalk A| | PubMed
  8. Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans.
    Rentsch D, Bergs A, Shao J, Elvers N, Ruse C, Seidenthal M, Aoki I, Gottschalk A| | PubMed
  9. Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.
    Aoki I, Golinelli L, Dunkel E, Bhat S, Bassam E, Beets I, Gottschalk A| | PubMed
  10. Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission.
    Dill H, Liewald JF, Becker M, Seidenthal M, Gottschalk A| | PubMed